2-Amino-2-methyl-1,3-propanediol → 5-Bromo-6-chloro-N-(1,3-dihydroxy-2-methylpropan-2-yl)pyridine-3-sulfonamide

HRID 558501

반응식

HRID 558501 반응식
[Br:1][C:2]1[C:3]([Cl:12])=[N:4][CH:5]=[C:6]([S:8](Cl)(=[O:10])=[O:9])[CH:7]=1.[NH2:13][C:14]([CH3:19])([CH2:17][OH:18])[CH2:15][OH:16]>>[OH:16][CH2:15][C:14]([NH:13][S:8]([C:6]1[CH:5]=[N:4][C:3]([Cl:12])=[C:2]([Br:1])[CH:7]=1)(=[O:10])=[O:9])([CH2:17][OH:18])[CH3:19]

참가 물질

3

반응물 2

HCID 15312-Amino-2-methyl-1,3-propanediolHCID 27936265-Bromo-6-chloropyridine-3-sulfonyl chloride

생성물 1

HCID 866079925-Bromo-6-chloro-N-(1,3-dihydroxy-2-methylpropan-2-yl)pyridine-3-sulfonamide수율 83.4%

실험 절차

Prepared by general procedure III from 3-bromo-2-chloropyridine-5-sulphonylchloride (580 mg, 2 mmol) and 2-amino-2-methyl-1,3-propanediol (231 mg, 2 mmol) to give 5-Bromo-6-chloro-pyridine-3-sulfonic acid (2-hydroxy-1-hydroxymethyl-1-methyl-ethyl)-amide (600 mg, 83%) as a yellow solid. MS (ISN) 357 [(M−H)−], 359.0 [(M+2−H)−], 361.0 [(M+4−H)−].

출처 및 근거

ORD 기록
ord-e1effc38f2bc4023a0214481c217e20c
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08063048B2

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