Hydrazine hydrate (1:1) → HCID 86608019, 화합물

HRID 558619노트

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HRID 558619 반응식
C(S[C:4](=[O:23])[CH:5]([C:19]([F:22])([F:21])[F:20])[CH2:6][C:7](=O)[C:8]1[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=1)C.O.[NH2:25][NH2:26]>CCO>[F:20][C:19]([F:22])([F:21])[CH:5]1[CH2:6][C:7]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)=[N:26][NH:25][C:4]1=[O:23]

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 86608017HCID 86608017, 화합물

생성물 1

HCID 86608019HCID 86608019, 화합물수율 100%

시약·촉매·용매 1

HCID 702Ethanol용매

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온도
23 °C

실험 절차

A mixture of 4-oxo-2-trifluoromethyl-4-(4-trifluoromethyl-phenyl)-thiobutyric acid S-ethyl ester (example C.26 step 4) (16.0 g, 45 mmol) and hydrazine monohydrate (2.39 mL, 49 mmol) in EtOH (250 mL) was refluxed for 18 h under nitrogen atmosphere. Cooled to 23° C., the solvents were evaporated to leave the title compound as a brown solid (13.83 g, 100%), which was used without further purification [according to Synthesis 2003, (3), 436.]. MS (ISP) 311.1 [(M+H)+]; mp 135-136° C.

후처리

  1. temperaturewas refluxed for 18 h under nitrogen atmosphere
  2. customthe solvents were evaporated

출처 및 근거

ORD 기록
ord-254a954c6d0e4686b58628485ecebeaa
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08063048B2

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