Sodium Bicarbonate → 5-Acetyl-6-methyl-N-[4-(methylsulfonyl)benzyl]-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide

HRID 559801

반응식

HRID 559801 반응식
C([O:5][C:6]([C:8]1[CH:9]=[C:10]([C:26]([NH:28][CH2:29][C:30]2[CH:35]=[CH:34][C:33]([S:36]([CH3:39])(=[O:38])=[O:37])=[CH:32][CH:31]=2)=[O:27])[C:11](=[O:25])[N:12]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:24])([F:23])[F:22])[CH:16]=2)[C:13]=1[CH3:14])=[CH2:7])CCC.C(=O)([O-])O.[Na+]>Cl>[C:6]([C:8]1[CH:9]=[C:10]([C:26]([NH:28][CH2:29][C:30]2[CH:35]=[CH:34][C:33]([S:36]([CH3:39])(=[O:38])=[O:37])=[CH:32][CH:31]=2)=[O:27])[C:11](=[O:25])[N:12]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:24])([F:23])[F:22])[CH:16]=2)[C:13]=1[CH3:14])(=[O:5])[CH3:7]

참가 물질

4

반응물 2

HCID 516892Sodium BicarbonateHCID 667254565-(1-Butoxyvinyl)-6-methyl-N-[4-(methylsulfonyl)benzyl]-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide

생성물 1

HCID 667252635-Acetyl-6-methyl-N-[4-(methylsulfonyl)benzyl]-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide수율 51.5%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

Aqueous hydrochloric acid (2.0M, 50 μl) was added to a solution of 5-(1-butoxyvinyl)-6-methyl-N-[4-(methylsulfonyl)benzyl]-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide (38 mg, 67.5 μmol) in DNT (0.5 ml). After 20 min. the solution was neutralized with aqueous sodium hydrogen carbonate. The reaction mixture was purified by preparative HPLC to give the title compound as a white solid (17.6 mg, 51%).

후처리

  1. customThe reaction mixture was purified by preparative HPLC

출처 및 근거

ORD 기록
ord-727b8d1c97a34d3daa701c02733a434b
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08063073B2

연결된 노트

불러오는 중…