Sodium hydride → 3-Isopropyl-4-(3'-methanesulfonyl-biphenyl-3-yl)-1-(5-methyl-isoxazole-4-sulfonyl)-imidazolidin-2-one

HRID 560099

반응식

HRID 560099 반응식
[CH:1]([N:4]1[CH:8]([C:9]2[CH:10]=[C:11]([C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([S:21]([CH3:24])(=[O:23])=[O:22])[CH:16]=3)[CH:12]=[CH:13][CH:14]=2)[CH2:7][NH:6][C:5]1=[O:25])([CH3:3])[CH3:2].[H-].[Na+].[CH3:28][C:29]1[O:33][N:32]=[CH:31][C:30]=1[S:34](Cl)(=[O:36])=[O:35]>>[CH:1]([N:4]1[CH:8]([C:9]2[CH:10]=[C:11]([C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([S:21]([CH3:24])(=[O:22])=[O:23])[CH:16]=3)[CH:12]=[CH:13][CH:14]=2)[CH2:7][N:6]([S:34]([C:30]2[CH:31]=[N:32][O:33][C:29]=2[CH3:28])(=[O:36])=[O:35])[C:5]1=[O:25])([CH3:3])[CH3:2]

참가 물질

4

반응물 3

HCID 24758Sodium hydrideHCID 27761415-Methyl-1,2-oxazole-4-sulfonyl chlorideHCID 670009481-Isopropyl-5-(3'-methanesulfonyl-biphenyl-3-yl)-imidazolidin-2-one

생성물 1

HCID 445480423-Isopropyl-4-(3'-methanesulfonyl-biphenyl-3-yl)-1-(5-methyl-isoxazole-4-sulfonyl)-imidazolidin-2-one

실험 절차

In analogy to example 13, step 2,1-isopropyl-5-(3′-methanesulfonyl-biphenyl-3-yl)-imidazolidin-2-one (example 13, step 1) was reacted with sodium hydride and 5-methyl-4-isoxazolesulfonyl chloride to give 3-isopropyl-4-(3′-methanesulfonyl-biphenyl-3-yl)-1-(5-methyl-isoxazole-4-sulfonyl)-imidazolidin-2-one as a light brown solid. MS: 502.4 ([M−H]−)

출처 및 근거

ORD 기록
ord-24809f6d131642a18f1b52cde79241cb
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08063088B2

연결된 노트

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