1,3-Difluoro-5-iodobenzene → C-(3,5-Difluoro-phenyl)-C-(1-pyrrolidin-1-yl-cyclobutyl)-methylamine

HRID 560200

반응식

HRID 560200 반응식
[N:1]1([C:6]2([C:10]#[N:11])[CH2:9][CH2:8][CH2:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[F:12][C:13]1[CH:14]=[C:15](I)[CH:16]=[C:17]([F:19])[CH:18]=1>>[F:12][C:13]1[CH:14]=[C:15]([CH:10]([NH2:11])[C:6]2([N:1]3[CH2:5][CH2:4][CH2:3][CH2:2]3)[CH2:7][CH2:8][CH2:9]2)[CH:16]=[C:17]([F:19])[CH:18]=1

참가 물질

3

반응물 2

HCID 27782211,3-Difluoro-5-iodobenzeneHCID 438027731-Pyrrolidin-1-yl-cyclobutanecarbonitrile2회

생성물 1

HCID 59197902C-(3,5-Difluoro-phenyl)-C-(1-pyrrolidin-1-yl-cyclobutyl)-methylamine

실험 절차

The title compound, yellow oil, MS: m/e=267.2 [(M+H)+], was prepared in accordance with the general method of intermediate K from 1-pyrrolidin-1-yl-cyclobutanecarbonitrile (intermediate F) and 3,5-difluoro-iodobenzene.

출처 및 근거

ORD 기록
ord-886f9cc5150e40308d57fac948aac89b
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08063098B2

연결된 노트

불러오는 중…