6-Chloroimidazo[2,1-b][1,3]thiazole-5-carbaldehyde → 6-Chloroimidazo[2,1-b][1,3]thiazole-5-carboxylic acid

HRID 560305노트

반응식

HRID 560305 반응식
Cl([O-])=O.[Na+].[OH2:5].O.P([O-])(O)(O)=O.[Na+].[Cl:13][C:14]1[N:15]=[C:16]2[N:20]([C:21]=1[CH:22]=[O:23])[CH:19]=[CH:18][S:17]2>O.C(O)(C)(C)C>[Cl:13][C:14]1[N:15]=[C:16]2[N:20]([C:21]=1[C:22]([OH:5])=[O:23])[CH:19]=[CH:18][S:17]2

참가 물질

6

반응물 3

HCID 3299506-Chloroimidazo[2,1-b][1,3]thiazole-5-carbaldehydeHCID 23668197Sodium ChloriteHCID 23673460Sodium Phosphate, Monobasic, Dihydrate

생성물 1

HCID 3299776-Chloroimidazo[2,1-b][1,3]thiazole-5-carboxylic acid

시약·촉매·용매 2

HCID 962Water용매HCID 6386tert-Butanol용매

실험 절차

A solution of sodium chlorite (230 mmol) and sodium dihydrogen phosphate dihydrate (176 mmol) in water (195 mL) is added dropwise to a solution of 6-chloro-imidazo[2,1-b]thiazole-5-carbaldehyde (26.8 mmol) in tert.-butanol (195 mL) and the mixture is stirred for 8 h at RT. The solvents are partially removed in vacuo and the obtained precipitate is filtered off. The filtrate is made acidic and the obtained precipitate is filtered off to give the desired product as a white solid.

후처리

  1. customThe solvents are partially removed in vacuo
  2. filtrationthe obtained precipitate is filtered off
  3. filtrationthe obtained precipitate is filtered off

출처 및 근거

ORD 기록
ord-a4c2b60627294f8090a8f0ede8077b7c
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08063099B2

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