Hydrochloric Acid → 2-Methyl-1,3-benzoxazole-4-carboxylic acid

HRID 560310

반응식

HRID 560310 반응식
[OH-].[K+].C([O:5][C:6]([C:8]1[CH:9]=[CH:10][CH:11]=[C:12]2[O:16][C:15]([CH3:17])=[N:14][C:13]=12)=[O:7])C.Cl>CO>[CH3:17][C:15]1[O:16][C:12]2[C:13](=[C:8]([C:6]([OH:7])=[O:5])[CH:9]=[CH:10][CH:11]=2)[N:14]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 593168402-Methyl-benzooxazole-4-carboxylic acid ethyl ester

생성물 1

HCID 183546282-Methyl-1,3-benzoxazole-4-carboxylic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

At 0° C. an aq. KOH solution (1.0 M, 2.40 mL) is added to a solution of 2-methyl-benzoxazole-4-carboxylic acid ethyl ester (0.98 mmol) in MeOH (5.0 mL) and stirred for 30 min. The mixture is allowed to reach RT, stirred for additional 60 min and made acidic by addition of aq. HCl (2.0 M). After removal of MeOH under reduced pressure the obtained precipitate is filtered off to give the desired product which is dried in vacuo. 1H-NMR (DMSO-d6): δ=2.64 (s, 3H); 7.41 (t, J=8.0 Hz, 1H); 7.83 (d, J=7.8 Hz, 1H); 7.88 (d, J=8.0 Hz, 1H); 12.8 (bs, 1H).

후처리

  1. customto reach RT
  2. stirringstirred for additional 60 min
  3. customAfter removal of MeOH under reduced pressure the obtained precipitate
  4. filtrationis filtered off

출처 및 근거

ORD 기록
ord-3ac663708b3540fc9dc064623712b8d0
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08063099B2

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