Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanol → Ethyl 4-chloro-3-hydroxybenzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sulfuric Acid | HCID 1118 | — |
| 반응물 | 4-Chloro-3-hydroxybenzoic acid | HCID 141872 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | Ethyl 4-chloro-3-hydroxybenzoate | HCID 58847555 | — |
반응 단계
A solution of 4-chloro-3-hydroxy-benzoic acid (29.3 mmol) in EtOH (110 mL) is treated with conc. sulfuric acid (23.6 mL) and heated to reflux for 16 h. Water (600 mL), NaHCO3 (100 g) and ether (300 mL) are added successively, the layers are separated and the aq. layer is extracted twice with ether. The combined organic layers are washed twice with brine, dried over MgSO4 and concentrated in vacuo to give the desired product which is used without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08063099B2 |
| 출처 데이터셋 | uspto-grants-2011_11 |
| ORD ID | ord-4a040cbe21bc4ea195dca19635252c09 |
| 출처 메모 | uspto-grants-2011_11 |