反应详情

A solution of 4-chloro-3-hydroxy-benzoic acid (29.3 mmol) in EtOH (110 mL) is treated with conc. sulfuric acid (23.6 mL) and heated to reflux for 16 h. Water (600 mL), NaHCO3 (100 g) and ether (300 mL) are added successively, the layers are separated and the aq. layer is extracted twice with ether. The combined organic layers are washed twice with brine, dried over MgSO4 and concentrated in vacuo to give the desired product which is used without further purification.

1. temperatureheated
2. temperatureto reflux for 16 h
3. customthe layers are separated
4. extractionthe aq. layer is extracted twice with ether
5. washThe combined organic layers are washed twice with brine
6. dry with materialdried over MgSO4
7. concentrationconcentrated in vacuo