Sodium Hydroxide → 2-Amino-4-methyl-thiazole-5-carboxylic acid
반응식
[NH2:1][C:2]1[S:3][C:4]([C:8]([O:10]CC)=[O:9])=[C:5]([CH3:7])[N:6]=1.[OH-].[Na+]>O1CCCC1.O>[NH2:1][C:2]1[S:3][C:4]([C:8]([OH:10])=[O:9])=[C:5]([CH3:7])[N:6]=1참가 물질
5
실험 절차
A mixture of ethyl 2-amino-4-methylthiazole-5-carboxylate (6.58 g, 35.5 mmol) and NaOH (5.40 g, 135 mmol) in tetrahydrofuran (60 mL) and water (30 mL) was heated to reflux overnight. Tetrahydrofuran was removed in vacuo, and the residue was neutralized with 5% hydrochloric acid solution to pH 5˜6. The precipitate obtained was collected by filtration and dried to afford the crude 2-amino-4-methylthiazole-5-carboxylic acid (5.20 g, 94%): 1H NMR (300 MHz, DMSO-d6) δ 7.63 (s, 2H), 2.30 (s, 3H); MS (ES+) m/z 159.1 (M+1).
후처리
- temperaturewas heated
- temperatureto reflux overnight
- customTetrahydrofuran was removed in vacuo
- customThe precipitate obtained
- filtrationwas collected by filtration
- customdried
출처 및 근거
- ORD 기록
- ord-45fc3713ccff472292b5824c2dd98953
- 출처 데이터셋
- uspto-grants-2011_11
- 특허 번호
- US08063084B2
반응 노트
불러오는 중…