Triphenylphosphine → HCID 55283830, 화합물

HRID 560566노트

반응식

HRID 560566 반응식
[N:1]([CH2:4][C:5]1[O:6][C:7]([CH:10]([F:12])[F:11])=[CH:8][CH:9]=1)=[N+]=[N-].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>O1CCCC1.O>[F:11][CH:10]([F:12])[C:7]1[O:6][C:5]([CH2:4][NH2:1])=[CH:9][CH:8]=1

참가 물질

5

반응물 2

HCID 11776TriphenylphosphineHCID 866452892-(Azidomethyl)-5-(difluoromethyl)furan

생성물 1

HCID 55283830HCID 55283830, 화합물수율 70%

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 2-(azidomethyl)-5-(difluoromethyl)furan (0.50 g, 2.92 mmol) in a mixture of tetrahydrofuran (10 mL) and water (1 mL) was added triphenylphosphine (1.15 g, 4.39 mmol). The reaction mixture was stirred at ambient temperature for 18 hours. The solvent was removed in vacuo and the residue was purified on strong cation exchange column to afford (5-(difluoromethyl)furan-2-yl)methanamine as a yellow oil in 70% yield (0.30 g): MS (ES+) m/z 3148.2 (M+1).

후처리

  1. customThe solvent was removed in vacuo
  2. customthe residue was purified on strong cation exchange column

출처 및 근거

ORD 기록
ord-b9762b1229464556805a9b28919527cb
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08063084B2

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