N-bromobutanimide → 1-(Bromomethyl)-2-fluoro-4-iodobenzene

HRID 56077

반응식

HRID 56077 반응식
[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[CH3:9].C1C(=O)N([Br:17])C(=O)C1>C(Cl)(Cl)(Cl)Cl>[Br:17][CH2:9][C:3]1[CH:4]=[CH:5][C:6]([I:8])=[CH:7][C:2]=1[F:1]

참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 1234922-Fluoro-4-iodotoluene

생성물 1

HCID 222404061-(Bromomethyl)-2-fluoro-4-iodobenzene수율 57.2%

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

To a solution of 2-fluoro-4-iodotoluene (2.83 g, 12 mmol) in CCl4 (120 mL) were added NBS (2.24 g, 12.6 mmol) and BPO (0.06 g, 0.24 mmol). The reaction mixture was refluxed for 9 h under N2, then cooled to rt and concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE) to give the title compound as a white solid (2.16 g, 57%).

후처리

  1. temperatureThe reaction mixture was refluxed for 9 h under N2
  2. concentrationconcentrated in vacuo
  3. customThe residue was purified by a silica gel column chromatography (PE)

출처 및 근거

ORD 기록
ord-0cfa3f3d637a4a8cbd5b9d467dbcdaa1
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434695B2

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