N-bromobutanimide → 1-(Bromomethyl)-2-fluoro-4-nitrobenzene

HRID 56080노트

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HRID 56080 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[F:11].C1C(=O)N([Br:19])C(=O)C1>C(Cl)(Cl)(Cl)Cl>[Br:19][CH2:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[F:11]

참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 740252-Fluoro-4-nitrotoluene

생성물 1

HCID 218861321-(Bromomethyl)-2-fluoro-4-nitrobenzene수율 60.5%

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

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온도
68 °C

실험 절차

To a solution of 1-methyl-2-fluoro-4-nitrobenzene (4.96 g, 32 mmol) and NBS (6.05 g, 34 mmol) in CCl4 (80 mL) was added BPO (0.39 g, 1.6 mmol). The mixture was heated at 68° C. for 5 h, then filtered and concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=20:1) to give the title compound as a yellow solid (4.53 g, 60%).

후처리

  1. filtrationfiltered
  2. concentrationconcentrated in vacuo
  3. customThe residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=20:1)

출처 및 근거

ORD 기록
ord-4d8fba4631d94be49db7eb7c30cb4eea
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434695B2

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