Ethyl Bromide → 2-(4-Ethoxyphenyl)thiazole

HRID 56085

반응식

HRID 56085 반응식
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][CH:10]=[CH:11][N:12]=2)=[CH:4][CH:3]=1.C([O-])([O-])=O.[K+].[K+].Br[CH2:20][CH3:21]>CC(C)=O>[CH2:20]([O:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[S:9][CH:10]=[CH:11][N:12]=2)=[CH:6][CH:7]=1)[CH3:21]

참가 물질

5

반응물 3

HCID 6332Ethyl BromideHCID 11430Potassium CarbonateHCID 2238404-(1,3-Thiazol-2-yl)phenol

생성물 1

HCID 691606082-(4-Ethoxyphenyl)thiazole수율 100%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a mixture of 2-(4-hydroxyphenyl)thiazole (21.27 g, 0.12 mol) and K2CO3 (82.93 g, 0.60 mol) in acetone (1000 mL) was added bromoethane (39.24 g, 0.36 mol) with stirring at rt. The reaction mixture was heated at 60° C. for 11 h, then cooled to rt, filtered and concentrated in vacuo to give the title compound as a white solid (24.54 g, 100%).

후처리

  1. temperatureThe reaction mixture was heated at 60° C. for 11 h
  2. temperaturecooled to rt
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-1ffa6d2b914f46358351db5fa944536d
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434695B2

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