Diisopropylethylamine → 3-[4-(2-Bromo-5-fluorophenoxy)piperidin-1-yl]-4,5-dihydroisoxazole-5-carboxamide

HRID 561207노트

반응식

HRID 561207 반응식
Br[C:2]1[CH2:6][CH:5]([C:7]([NH2:9])=[O:8])[O:4][N:3]=1.[Br:10][C:11]1[CH:23]=[CH:22][C:21]([F:24])=[CH:20][C:12]=1[O:13][CH:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1.C(N(CC)C(C)C)(C)C>C(O)C>[Br:10][C:11]1[CH:23]=[CH:22][C:21]([F:24])=[CH:20][C:12]=1[O:13][CH:14]1[CH2:15][CH2:16][N:17]([C:2]2[CH2:6][CH:5]([C:7]([NH2:9])=[O:8])[O:4][N:3]=2)[CH2:18][CH2:19]1

참가 물질

5

반응물 3

HCID 81531DiisopropylethylamineHCID 441183083-Bromo-4,5-dihydro-1,2-oxazole-5-carboxamideHCID 578327574-(2-Bromo-5-fluorophenoxy)piperidine

생성물 1

HCID 666968003-[4-(2-Bromo-5-fluorophenoxy)piperidin-1-yl]-4,5-dihydroisoxazole-5-carboxamide

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 3-bromo-4,5-dihydroisoxazole-5-carboxamide (1.5 g, 7.77 mmol), 4-(2-bromo-5-fluorophenoxy)piperidine (2.56 g, 9.33 mmol) and N,N-diisopropylethylamine (3.5 mL, 20.04 mmol) in ethanol (15 mL) was heated at reflux temperature overnight. Solvent was then removed in vacuo. The residue was suspended in water and stirred for 1 h. The solid was collected, washed with water and Et2O. Drying under vacuum gave the title compound as a light brown powder.

후처리

  1. temperaturewas heated
  2. temperatureat reflux temperature overnight
  3. customSolvent was then removed in vacuo
  4. customThe solid was collected
  5. washwashed with water and Et2O
  6. customDrying under vacuum

출처 및 근거

ORD 기록
ord-b38cba21652543928f35c93aff5fce0f
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08063224B2

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