Hydrochloric Acid → HCID 39239624, 화합물

HRID 56126노트

반응식

HRID 56126 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)=[CH:4][C:3]=1[NH:14]C(=O)OC(C)(C)C.Cl>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)=[CH:4][C:3]=1[NH2:14]

참가 물질

3

반응물 2

HCID 313Hydrochloric AcidHCID 118262719HCID 118262719, 화합물

생성물 1

HCID 39239624HCID 39239624, 화합물수율 57%

실험 절차

A mixture of tert-butyl (2-fluoro-5-morpholinophenyl)carbamate (0.93 g, 3.14 mmol) and a solution of HCl (31 mL, 31 mmol, 1 M in MeOH) was stirred at rt overnight, then concentrated in vacuo. The residue was dissolved in water (150 mL). The soltution was basified with saturated Na2CO3 aqueous solution and extracted with CH2Cl2 (100 mL×3). The combined organic phases were washed with brine (150 mL), dried over anhydrous Na2SO4 and concentrated in vacuo to give the title compound as a light brown solid (0.35 g, 57%).

후처리

  1. concentrationconcentrated in vacuo
  2. dissolutionThe residue was dissolved in water (150 mL)
  3. extractionextracted with CH2Cl2 (100 mL×3)
  4. washThe combined organic phases were washed with brine (150 mL)
  5. dry with materialdried over anhydrous Na2SO4
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-33996a3ebf724b6d8c56b7826513c065
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434695B2

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