Pyridine → 1-Benzyl-3-methyl-piperidin-4-one oxime
반응식
[CH2:1]([N:8]1[CH2:13][CH2:12][C:11](=O)[CH:10]([CH3:15])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.N1C=CC=CC=1.Cl.[NH2:23][OH:24]>CCO>[CH2:1]([N:8]1[CH2:13][CH2:12][C:11](=[N:23][OH:24])[CH:10]([CH3:15])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1참가 물질
5
반응 조건
- 온도
- 90 °C
실험 절차
To a solution of 1-benzyl-3-methyl-piperidin-4-one (2.04 g, 10 mmol) in EtOH (20 mL), was added pyridine (20 mL, 0.25 mol) and hydroxylamine hydrochloride (0.70 g, 10 mmol). After being stirred at 90° C. overnight, the resultant solution was concentrated in vacuo to give the crude product 1-benzyl-3-methyl-piperidin-4-one oxime. LCMS m/z: 219 (M+H)+. This material was used without further purification.
후처리
- concentrationthe resultant solution was concentrated in vacuo
출처 및 근거
- ORD 기록
- ord-86f1b0acf74a4405a44cb6e72f54efa1
- 출처 데이터셋
- uspto-grants-2011_11
- 특허 번호
- US08063222B2
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