Methanol → HCID 438674, 화합물

HRID 5613노트

반응식

HRID 5613 반응식
[NH2:1][CH:2]([C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[NH:10][CH:9]=1)[C:3]([O:5]CC)=[O:4].[OH-].[Na+].CO>C(O)(=O)C>[NH2:1][CH:2]([C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[NH:10][CH:9]=1)[C:3]([OH:5])=[O:4]

참가 물질

5

반응물 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 11218231Ethyl 2-amino-2-(1H-indol-3-yl)acetate

생성물 1

HCID 438674HCID 438674, 화합물

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A mixture of 2 g of ethyl α-aminoindole-3-acetate, excess dilute NaOH solution, and a few mL of MeOH was stirred occasionally for 25 minutes. Since a solution had not been obtained, the mixture was heated on a steam bath for ten minutes. The resulting solution was allowed to stand at ambient temperature for 50 minutes. The solution was acidified with acetic acid. The solid which separated was collected by filtration and washed with H2O giving 1.50 g (86%) of the title compound as small buff plates, m.p. 217° (dec).

후처리

  1. customSince a solution had not been obtained
  2. temperaturethe mixture was heated on a steam bath for ten minutes
  3. customThe solid which separated
  4. filtrationwas collected by filtration
  5. washwashed with H2O giving 1.50 g (86%) of the title compound as small buff plates, m.p. 217° (dec)

출처 및 근거

ORD 기록
ord-69fd0f6486c34ef8b949897a3d4dc910
출처 데이터셋
uspto-grants-1993_09
특허 번호
US05245046

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