Triethylamine → 1-(2-Fluoro-4-nitrophenyl)pyrrolidine
반응식
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.CCN(CC)CC.F[C:14]1[CH:19]=[CH:18][C:17]([N+:20]([O-:22])=[O:21])=[CH:16][C:15]=1[F:23]>CCOC(C)=O>[F:23][C:15]1[CH:16]=[C:17]([N+:20]([O-:22])=[O:21])[CH:18]=[CH:19][C:14]=1[N:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1참가 물질
5
실험 절차
To a solution of pyrrolidine (0.78 g, 11 mmol) in EtOAc (15 mL) and Et3N (1.52 g, 15 mmol) was added 1,2-difluoro-4-nitrobenzene (1.59 g, 10 mmol) in an ice bath. The mixture was stirred at rt overnight and filtered. The filter cake was washed with water and dried to give the title compound as a yellow solid (1.60 g, 76%).
후처리
- filtrationfiltered
- washThe filter cake was washed with water
- customdried
출처 및 근거
- ORD 기록
- ord-a7582baf64854ba5b5559c0c8b53739c
- 출처 데이터셋
- uspto-grants-2016_09
- 특허 번호
- US09434695B2
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