4-Chloro-alpha-cyclopropyl-alpha-methylbenzenemethanol → alpha-Cyclopropyl-2,3-dihydro-alpha-methyl-1,4-benZodioxin-6-methanol

HRID 561466

반응식

HRID 561466 반응식
[CH3:1][C:2]([C:4]1[CH:13]=[CH:12][C:7]2[O:8][CH2:9][CH2:10][O:11][C:6]=2[CH:5]=1)=[O:3].[CH:14]1([Mg]Br)[CH2:16][CH2:15]1.C1(C(C2C=CC(Cl)=CC=2)(O)C)CC1>O1CCCC1>[CH:14]1([C:2]([C:4]2[CH:13]=[CH:12][C:7]3[O:8][CH2:9][CH2:10][O:11][C:6]=3[CH:5]=2)([OH:3])[CH3:1])[CH2:16][CH2:15]1

참가 물질

5

반응물 3

HCID 234634-Chloro-alpha-cyclopropyl-alpha-methylbenzenemethanolHCID 761431,4-Benzodioxan-6-yl methyl ketoneHCID 178418630HCID 178418630, 화합물

생성물 1

HCID 58392439alpha-Cyclopropyl-2,3-dihydro-alpha-methyl-1,4-benZodioxin-6-methanol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

The title compound was prepared starting from 1.50 g (8.42 mmol) of 1,4-benzodioxan-6-yl methyl ketone and 33.7 ml (16.84 mmol) of a 0.5N solution of cyclopropylmagnesium bromide in tetrahydrofuran in analogy to the synthesis of the compound from Example 138A. 1.12 g (59% of theory) of the title compound were obtained.

후처리

  1. customThe title compound was prepared

출처 및 근거

ORD 기록
ord-1cc945a37750462c96a318d87a9744c5
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08063234B2

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