4-Chloro-alpha-cyclopropyl-alpha-methylbenzenemethanol → 1-(Benzo[d][1,3]dioxol-5-yl)-1-cyclopropylethanol

HRID 561467

반응식

HRID 561467 반응식
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]2[O:10][CH2:11][O:12][C:6]=2[CH:5]=1)=[O:3].[CH:13]1([Mg]Br)[CH2:15][CH2:14]1.C1(C(C2C=CC(Cl)=CC=2)(O)C)CC1>O1CCCC1>[O:10]1[C:7]2[CH:8]=[CH:9][C:4]([C:2]([CH:13]3[CH2:15][CH2:14]3)([OH:3])[CH3:1])=[CH:5][C:6]=2[O:12][CH2:11]1

참가 물질

5

반응물 3

HCID 234634-Chloro-alpha-cyclopropyl-alpha-methylbenzenemethanolHCID 76622AcetopiperoneHCID 178418630HCID 178418630, 화합물

생성물 1

HCID 583922611-(Benzo[d][1,3]dioxol-5-yl)-1-cyclopropylethanol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

The title compound was prepared starting from 1.50 g (9.14 mmol) of 3,4-(methylenedioxy)acetophenone and 36.5 ml (18.28 mmol) of a 0.5N solution of cyclopropylmagnesium bromide in tetrahydrofuran in analogy to the synthesis of the compound from Example 138A. 1.32 g (70% of theory) of the title compound were obtained.

후처리

  1. customThe title compound was prepared

출처 및 근거

ORD 기록
ord-83377f42d1354a9da6ac332978b01b77
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08063234B2

연결된 노트

불러오는 중…