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4-(2-Bromo-1,3-thiazol-5-yl)-4-{7-[(methylsulfanyl)methyl]-1H-indol-3-yl}butanonitrile → 4-(4-Chlorophenyl)-3-methyl-4-{7-[(methylsulfanyl)methyl]-1H-indol-3-yl}butanonitrile

HRID 561559
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HRID 561559 반응식
CS(O[CH2:6][CH:7]([CH3:28])[CH:8]([C:21]1[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=1)[C:9]1[C:17]2[C:12](=[C:13]([CH2:18][S:19][CH3:20])[CH:14]=[CH:15][CH:16]=2)[NH:11][CH:10]=1)(=O)=O.Br[C:30]1SC(C(C2C3C(=C(CSC)C=CC=3)NC=2)CCC#N)=C[N:34]=1>CS(C)=O>[Cl:27][C:24]1[CH:25]=[CH:26][C:21]([CH:8]([C:9]2[C:17]3[C:12](=[C:13]([CH2:18][S:19][CH3:20])[CH:14]=[CH:15][CH:16]=3)[NH:11][CH:10]=2)[CH:7]([CH3:28])[CH2:6][C:30]#[N:34])=[CH:22][CH:23]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

4

반응물 2

HCID 583921014-(2-Bromo-1,3-thiazol-5-yl)-4-{7-[(methylsulfanyl)methyl]-1H-indol-3-yl}butanonitrileHCID 583924653-(4-Chlorophenyl)-2-methyl-3-{7-[(methylsulfanyl)methyl]-1H-indol-3-yl}propyl methanesulfonate

생성물 1

HCID 583921084-(4-Chlorophenyl)-3-methyl-4-{7-[(methylsulfanyl)methyl]-1H-indol-3-yl}butanonitrile

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

The title compound was prepared starting from 215 mg (0.49 mmol) of the compound from Example 71A in analogy to the synthesis of the compound from Example 53, but with dimethyl sulfoxide as solvent. 177 mg (98% of theory) of the target compound were obtained as mixture of diastereomers.

후처리

  1. custom177 mg (98% of theory) of the target compound were obtained as mixture of diastereomers

출처 및 근거

ORD 기록
ord-a1a6824b6d814218a90641526cf03292
출처 데이터셋
uspto-grants-2011_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08063234B2

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