Hexylamine → 2-Fluoro-n-hexyl-4-nitroaniline

HRID 56177

반응식

HRID 56177 반응식
[F:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:6][C:7]=1F.CCN(CC)CC.[CH2:19]([NH2:25])[CH2:20][CH2:21][CH2:22][CH2:23][CH3:24]>CCOC(C)=O>[F:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:6][C:7]=1[NH:25][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24]

참가 물질

5

반응물 3

HCID 8102HexylamineHCID 8471TriethylamineHCID 1230531,2-Difluoro-4-nitrobenzene

생성물 1

HCID 5980562-Fluoro-n-hexyl-4-nitroaniline수율 91%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 3,4-difluoronitrobenzene (3.18 g, 20 mmol) in EtOAc (50 mL) were added Et3N (2.43 g, 24 mmol) and hexan-1-amine (2.02 g, 20 mmol). The reaction mixture was refluxed overnight, then cooled to rt and concentrated in vacuo to give the title compound as yellow oil (4.37 g, 91%).

후처리

  1. temperatureThe reaction mixture was refluxed overnight
  2. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-2ba673d1d82046bf98c0437cb95eb1a4
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434695B2

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