Triethylamine → N-(3-ethoxypropyl)-2-fluoro-4-nitroaniline

HRID 56180

반응식

HRID 56180 반응식
[F:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:6][C:7]=1F.CCN(CC)CC.[CH2:19]([O:21][CH2:22][CH2:23][CH2:24][NH2:25])[CH3:20]>CCOC(C)=O>[CH2:19]([O:21][CH2:22][CH2:23][CH2:24][NH:25][C:7]1[CH:6]=[CH:5][C:4]([N+:9]([O-:11])=[O:10])=[CH:3][C:2]=1[F:1])[CH3:20]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 22720Propanolamine ethyl etherHCID 1230531,2-Difluoro-4-nitrobenzene

생성물 1

HCID 28972577N-(3-ethoxypropyl)-2-fluoro-4-nitroaniline수율 90%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 3,4-difluoronitrobenzene (6.36 g, 40 mmol) in EtOAc (60 mL) were added Et3N (12.14 g, 120 mmol) and 3-ethoxypropan-1-amine (4.54 g, 44 mmol). The reaction mixture was refluxed overnight, then cooled to rt and concentrated in vacuo to give the title compound as yellow oil (8.68 g, 90%).

후처리

  1. temperatureThe reaction mixture was refluxed overnight
  2. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-c1932aaead9146289c1cb1541dfbdc8b
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434695B2

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