Hydrochloric Acid → 3-Amino-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-N-[3-(3-methoxypropyl)-5-(2-pyridin-2-ylethoxy)benzyl]propanamide

HRID 561878노트

반응식

HRID 561878 반응식
[CH:1]1([N:4]([CH2:37][C:38]2[CH:43]=[C:42]([O:44][CH2:45][CH2:46][C:47]3[CH:52]=[CH:51][CH:50]=[CH:49][N:48]=3)[CH:41]=[C:40]([CH2:53][CH2:54][CH2:55][O:56][CH3:57])[CH:39]=2)[C:5](=[O:36])[CH:6]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([O:23][CH2:24][CH2:25][O:26][C:27]3[C:32]([Cl:33])=[CH:31][C:30]([CH3:34])=[CH:29][C:28]=3[Cl:35])=[CH:19][CH:18]=2)[CH2:7][NH:8]C(=O)OC(C)(C)C)[CH2:3][CH2:2]1.Cl>C(Cl)Cl>[NH2:8][CH2:7][CH:6]([CH2:16][C:17]1[CH:18]=[CH:19][C:20]([O:23][CH2:24][CH2:25][O:26][C:27]2[C:32]([Cl:33])=[CH:31][C:30]([CH3:34])=[CH:29][C:28]=2[Cl:35])=[CH:21][CH:22]=1)[C:5]([N:4]([CH:1]1[CH2:2][CH2:3]1)[CH2:37][C:38]1[CH:43]=[C:42]([O:44][CH2:45][CH2:46][C:47]2[CH:52]=[CH:51][CH:50]=[CH:49][N:48]=2)[CH:41]=[C:40]([CH2:53][CH2:54][CH2:55][O:56][CH3:57])[CH:39]=1)=[O:36]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 86635939tert-Butyl (3-{cyclopropyl[3-(3-methoxypropyl)-5-(2-pyridin-2-ylethoxy)benzyl]amino}-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxopropyl)carbamate

생성물 1

HCID 159812523-Amino-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-N-[3-(3-methoxypropyl)-5-(2-pyridin-2-ylethoxy)benzyl]propanamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a CH2Cl2 solution (0.03 M) of tert-butyl (3-{cyclopropyl[3-(3-methoxypropyl)-5-(2-pyridin-2-ylethoxy)benzyl]amino}-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxopropyl)carbamate from the previous step (1 eq.) was added HCl (4.0 M dioxane solution, 30 eq.). The resulting solution was stirred at RT for 12 h. Following the removal of the volatiles in vacuo, the resulting residue was directly subjected to column chromatography (SiO2, 90:10 (v/v) CH2Cl2: 2.0 M NH3 in MeOH) to afford the title compound as a white froth. MS (ESI+): 720.0.

후처리

  1. customthe removal of the volatiles in vacuo

출처 및 근거

ORD 기록
ord-6ae1a20d51574caf9a8311e36ad3807e
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08063105B2

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