4-Nitrophthalimide → 4-Aminophthalimide

HRID 562026노트

반응식

HRID 562026 반응식
[N+:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[C:9](=[O:13])[NH:8][C:7]2=[O:14])([O-])=O>C1COCC1.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[C:9](=[O:13])[NH:8][C:7]2=[O:14]

참가 물질

4

반응물 1

HCID 69694-Nitrophthalimide

생성물 1

HCID 729154-Aminophthalimide수율 59.3%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 5-nitro-1H-isoindole-1,3(2H)-dione (1.0 g, 5.2 mmol) in dry THF (15 mL) was added 10% Pd/C (0.2 g). The mixture was hydrogenated at 30-40 psi for 17 h. The catalyst was filtered, and the filtrate was evaporated under vacuo to give 0.5 g (59.3%) of 5-amino-1H-isoindole-1,3(2H)-dione as a yellow colour solid.

후처리

  1. filtrationThe catalyst was filtered
  2. customthe filtrate was evaporated under vacuo

출처 및 근거

ORD 기록
ord-2458169eb719478ca251f97f20fc7584
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08063071B2

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