Hydrochloric Acid → 5-bromo-3-(4-piperidinyl)-1H-indole-7-carboxamide hydrochloride

HRID 562029

반응식

HRID 562029 반응식
[ClH:1].[NH2:2][C:3]([C:5]1[CH:6]=[C:7]([Br:27])[CH:8]=[C:9]2[C:13]=1[NH:12][CH:11]=[C:10]2[CH:14]1[CH2:19][CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16][CH2:15]1)=[O:4]>O1CCOCC1.CO>[ClH:1].[Br:27][C:7]1[CH:8]=[C:9]2[C:13](=[C:5]([C:3]([NH2:2])=[O:4])[CH:6]=1)[NH:12][CH:11]=[C:10]2[CH:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 59600660tert-butyl 4-(5-bromo-7-carbamoyl-1H-indol-3-yl)piperidine-1-carboxylate

생성물 1

HCID 667232845-bromo-3-(4-piperidinyl)-1H-indole-7-carboxamide hydrochloride

시약·촉매·용매 2

HCID 887Methanol용매HCID 312751,4-Dioxane용매

실험 절차

A 4M solution of HCl in dioxane (194 mL) was added to a solution of 1,1-dimethylethyl 4-[7-(aminocarbonyl)-5-bromo-1H-indol-3-yl]-1-piperidinecarboxylate (10 g, 23.7 mmol) in methanol (50 mL). The reaction mixture was stirred at room temperature for 4 hours, and the solvent was evaporated under reduced pressure to give the title compound (9.5 g), which was used in the next step without further purification.

후처리

  1. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-e3c06bea0b0c42e3b1cc8fcc7ab25cad
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08063071B2

연결된 노트

불러오는 중…