2-Furanpropionic acid → 3-(Oxolan-2-yl)propanoic acid

HRID 56215

반응식

HRID 56215 반응식
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7][C:8]([OH:10])=[O:9]>CO.[Pd]>[O:1]1[CH2:5][CH2:4][CH2:3][CH:2]1[CH2:6][CH2:7][C:8]([OH:10])=[O:9]

참가 물질

4

반응물 1

HCID 702862-Furanpropionic acid

생성물 1

HCID 2631613-(Oxolan-2-yl)propanoic acid

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

반응 조건

온도
60 °C

실험 절차

A mixture of 3-(furan-2-yl)propanoic acid (11.0 g, 80.0 mmol) and Pd/C (1.1 g, 10%) in MeOH (110 mL) was stirred at 60° C. under 30 bar of H2 overnight. The mixture was then filtered and the filtrate was concentrated in vacuo to give the title compound, which was used for next step without further purification.

후처리

  1. filtrationThe mixture was then filtered
  2. concentrationthe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-9f3c11f0258740c08bd5d0b5b6d2e178
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434695B2

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