Nitrogen → 2-Furanpropanol, tetrahydro-

HRID 56216

반응식

HRID 56216 반응식
[O:1]1[CH2:5][CH2:4][CH2:3][CH:2]1[CH2:6][CH2:7][C:8](O)=[O:9].B.N#N>C1COCC1>[O:1]1[CH2:5][CH2:4][CH2:3][CH:2]1[CH2:6][CH2:7][CH2:8][OH:9]

참가 물질

5

반응물 3

HCID 947NitrogenHCID 6331BoraneHCID 2631613-(Oxolan-2-yl)propanoic acid

생성물 1

HCID 130202-Furanpropanol, tetrahydro-

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 3-(tetrahydrofuran-2-yl)propanoic acid (11.5 g, 80.0 mmol) in anhydrous THF (200 mL) was added borane (160 mL, 160 mmol, 1 mol/L in THF) dropwise under N2 and the mixture was stirred at rt overnight. The reaction mixture was quenched with MeOH and concentrated in vacuo to give the title compound, which was used for next step without further purification.

후처리

  1. customThe reaction mixture was quenched with MeOH
  2. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-7a75b33b4b474dd5a6abbe7fc9ad701c
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434695B2

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