Imidazole → ethyl 2-(1H-imidazol-1-yl)acetate

HRID 562445노트

반응식

HRID 562445 반응식
[Na].[NH:2]1[CH:6]=[CH:5][N:4]=[CH:3]1.Br[CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10]>C(O)C>[N:2]1([CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:6]=[CH:5][N:4]=[CH:3]1

참가 물질

5

반응물 3

HCID 795ImidazoleHCID 7748Ethyl bromoacetateHCID 5360545Sodium

생성물 1

HCID 3798501ethyl 2-(1H-imidazol-1-yl)acetate

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

118.2 g (5.1 mmol) of sodium are added slowly to 2.5 litres of ethanol. 350.0 g (5.1 mol) of imidazole and 570 ml (858.6 g, 5.1 mol) of ethyl bromoacetate are added dropwise at an internal temperature of 20-25° C. The mixture is stirred at RT for 24 h. The precipitated solid is filtered off, the ethanol is removed under reduced pressure and the mixture is filtered again. The residue is purified by column chromatography on silica gel (mobile phase ethyl acetate). Yield: 639.0 g (81% of theory)

후처리

  1. filtrationThe precipitated solid is filtered off
  2. customthe ethanol is removed under reduced pressure
  3. filtrationthe mixture is filtered again
  4. customThe residue is purified by column chromatography on silica gel (mobile phase ethyl acetate)

출처 및 근거

ORD 기록
ord-2c36d1f0258c4a30833050141901c87b
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08067407B2

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