Sodium Hydroxide → 1-(6-Chloropyrimidin-4-yl)azetidin-3-ol

HRID 562453노트

반응식

HRID 562453 반응식
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[CH:4][N:3]=1.[OH-].[Na+].[OH:11][CH:12]1[CH2:15][NH:14][CH2:13]1>O>[Cl:8][C:6]1[N:5]=[CH:4][N:3]=[C:2]([N:14]2[CH2:15][CH:12]([OH:11])[CH2:13]2)[CH:7]=1

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 709434,6-DichloropyrimidineHCID 15142903-Hydroxyazetidine

생성물 1

HCID 579250791-(6-Chloropyrimidin-4-yl)azetidin-3-ol

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
90 °C

실험 절차

7.3 g (48.7 mmol) of 4,6-dichloropyrimidine are suspended in 140 ml of water, and 47 ml 1 N aqueous sodium hydroxide solution are added. 5.3 g (48.7 mmol) of 3-hydroxyazetidine are added, and the reaction mixture is stirred at 90° C. for 3 d. After cooling to RT, the reaction mixture is concentrated under reduced pressure and reacted further without further purification.

후처리

  1. temperatureAfter cooling to RT
  2. concentrationthe reaction mixture is concentrated under reduced pressure
  3. customreacted further without further purification

출처 및 근거

ORD 기록
ord-9ac6158955864f2aa78d7c64f0ec1ce0
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08067407B2

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