Hydrazine hydrate (1:1) → 1-(6-Hydrazinopyrimidin-4-yl)azetidin-3-ol

HRID 562454노트

반응식

HRID 562454 반응식
O.[NH2:2][NH2:3].Cl[C:5]1[N:10]=[CH:9][N:8]=[C:7]([N:11]2[CH2:14][CH:13]([OH:15])[CH2:12]2)[CH:6]=1>C(O)C>[NH:2]([C:5]1[N:10]=[CH:9][N:8]=[C:7]([N:11]2[CH2:14][CH:13]([OH:15])[CH2:12]2)[CH:6]=1)[NH2:3]

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 579250791-(6-Chloropyrimidin-4-yl)azetidin-3-ol

생성물 1

HCID 552790421-(6-Hydrazinopyrimidin-4-yl)azetidin-3-ol

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
80 °C

실험 절차

At RT, 27.2 ml (27.9 g, 279.1 mmol) of hydrazine hydrate are added dropwise with stirring to a solution of 10.4 g (55.8 mmol) of 1-(6-chloropyrimidin-4-yl)azetidin-3-ol in 100 ml of ethanol. The reaction solution is stirred at 80° C. for 16 h. For work-up, the mixture is concentrated under reduced pressure, and the precipitate is filtered off and washed twice with in each case 10 ml of ethanol. Yield: 2.0 g (19% of theory)

후처리

  1. concentrationFor work-up, the mixture is concentrated under reduced pressure
  2. filtrationthe precipitate is filtered off
  3. washwashed twice with in each case 10 ml of ethanol

출처 및 근거

ORD 기록
ord-a0ab5f8bbc7d423cab23fc8cc0f6f498
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08067407B2

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