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N,N-Dimethylethylenediamine → 6-Amino-2-butoxy-9-(3-{[2-(dimethylamino)ethyl]amino}propyl)-7,9-dihydro-8H-purin-8-one, hydrochloride

HRID 562493
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인쇄 미리보기

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HRID 562493 반응식
[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][CH3:15])[N:8]=[C:7]2[C:3]=1[NH:4][C:5](=[O:20])[N:6]2[CH2:16][CH2:17][CH2:18][Cl:19].[CH3:21][N:22]([CH3:26])[CH2:23][CH2:24][NH2:25]>CS(C)=O>[ClH:19].[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][CH3:15])[N:8]=[C:7]2[C:3]=1[NH:4][C:5](=[O:20])[N:6]2[CH2:16][CH2:17][CH2:18][NH:25][CH2:24][CH2:23][N:22]([CH3:26])[CH3:21]
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참가 물질

4

반응물 2

HCID 66053N,N-DimethylethylenediamineHCID 674649416-Amino-9-(3-chloropropyl)-2-butoxy-7,9-dihydro-8H-purin-8-one

생성물 1

HCID 1317292896-Amino-2-butoxy-9-(3-{[2-(dimethylamino)ethyl]amino}propyl)-7,9-dihydro-8H-purin-8-one, hydrochloride

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

반응 조건

온도
0 °C

실험 절차

The product of step (ii) (16 g), DMSO (16 ml) and N,N-dimethylethylenediamine (120 ml) was heated at 80° C. for 4 h then evaporated under reduced pressure. The residue was azeotroped with acetonitrile then heated under reflux in acetonitrile (250 ml) for 30 min then cooled to 0° C. for 1 h. The solid was filtered off and dried. Yield 15.32 g.

후처리

  1. customthen evaporated under reduced pressure
  2. customThe residue was azeotroped with acetonitrile
  3. temperaturethen heated
  4. temperatureunder reflux in acetonitrile (250 ml) for 30 min
  5. filtrationThe solid was filtered off
  6. customdried

출처 및 근거

ORD 기록
ord-c9ea2d24ee1745039cf96c85d5619aa6
출처 데이터셋
uspto-grants-2011_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08067411B2

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