3-Hydroxypyridine → 2-(Pyridin-3-yloxy)acetonitrile

HRID 56268노트

반응식

HRID 56268 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([OH:7])[CH:2]=1.C([O-])([O-])=O.[K+].[K+].Br[CH2:15][C:16]#[N:17]>CC#N>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([O:7][CH2:15][C:16]#[N:17])[CH:2]=1

참가 물질

5

반응물 3

HCID 79713-HydroxypyridineHCID 11430Potassium CarbonateHCID 11534Bromoacetonitrile

생성물 1

HCID 199146182-(Pyridin-3-yloxy)acetonitrile수율 16%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

To a mixture of pyridin-3-ol (4.0 g, 42.1 mmol) and K2CO3 (6.96 g, 50.4 mmol) in CH3CN (6 mL) was added dropwise 2-bromoacetonitrile (2.52 g, 21.0 mmol) at rt and the mixture was stirred at rt for 40 h. The mixture was filtered and the filtrate was concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=2:1) to give the title compound as a yellow solid (0.45 g, 16%).

후처리

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated in vacuo
  3. customThe residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=2:1)

출처 및 근거

ORD 기록
ord-bf1779f436194aab9f739c5a14f10a16
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434695B2

반응 노트

불러오는 중…