Nitrogen → 2-(3-Fluorophenoxy)-2-methylpropanoyl chloride

HRID 56276

반응식

HRID 56276 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][CH:14]=1)[O:5][C:6]([CH3:11])([CH3:10])[C:7](O)=[O:8].[Cl:15]SCl.N#N>>[F:1][C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][CH:14]=1)[O:5][C:6]([CH3:11])([CH3:10])[C:7]([Cl:15])=[O:8]

참가 물질

4

반응물 3

HCID 947NitrogenHCID 25353Sulfur dichlorideHCID 222707202-(3-fluorophenoxy)-2-methylPropanoic acid

생성물 1

HCID 821138502-(3-Fluorophenoxy)-2-methylpropanoyl chloride

실험 절차

To 2-(3-fluorophenoxy)-2-methylpropanoic acid (1.70 g, 8.58 mmol) was added dichlorosulfane (15 mL) dropwise under N2 and the mixture was refluxed for 3 h. The mixture was cooled to rt and concentrated in vacuo to give the title compound as yellow oil, which was used for next step without further purification.

후처리

  1. temperaturethe mixture was refluxed for 3 h
  2. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-9e3a5970c34243519043534d48bb17a0
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434695B2

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