3-Fluorophenol → 2-(3-Fluorophenoxy)acetamide

HRID 56278

반응식

HRID 56278 반응식
[F:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.Br[CH2:10][C:11]([NH2:13])=[O:12].C([O-])([O-])=O.[K+].[K+].C([O-])([O-])=O.[Cs+].[Cs+]>CC(C)=O>[F:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][CH:7]=1)[O:8][CH2:10][C:11]([NH2:13])=[O:12]

참가 물질

6

반응물 4

HCID 97433-FluorophenolHCID 10796Cesium carbonateHCID 11430Potassium CarbonateHCID 696322-Bromoacetamide

생성물 1

HCID 189381052-(3-Fluorophenoxy)acetamide수율 30%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 3-fluorophenol (11.2 g, 100 mmol), 2-bromoacetamide (13.8 g, 100 mmol), K2CO3 (13.82 g, 100 mmol) and Cs2CO3 (32.58 g, 100 mmol) in acetone (150 mL) was refluxed overnight. The mixture was cooled to rt and filtered and the filtrate was concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=1:1) to give the title compound as a white solid (5.06 g, 30%).

후처리

  1. temperaturewas refluxed overnight
  2. filtrationfiltered
  3. concentrationthe filtrate was concentrated in vacuo
  4. customThe residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=1:1)

출처 및 근거

ORD 기록
ord-7eb07fbcc8ef449b86ac184e3c4a8ea6
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434695B2

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