1-Bromo-2-methylpropane → 5-Bromo-2-isobutoxybenzonitrile

HRID 562883

반응식

HRID 562883 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([OH:10])=[C:6]([CH:9]=1)[C:7]#[N:8].[CH2:11](Br)[CH:12]([CH3:14])[CH3:13].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C.[Br-].C([N+](CCCC)(CCCC)CCCC)CCC>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:10][CH2:11][CH:12]([CH3:14])[CH3:13])=[C:6]([CH:9]=1)[C:7]#[N:8]

참가 물질

6

반응물 3

HCID 65551-Bromo-2-methylpropaneHCID 11430Potassium CarbonateHCID 27570145-Bromo-2-hydroxybenzonitrile

생성물 1

HCID 665851345-Bromo-2-isobutoxybenzonitrile

시약·촉매·용매 2

HCID 74236Tetrabutylammonium Bromide촉매HCID 6228Dimethylformamide용매

실험 절차

5-Bromo-2-hydroxybenzonitrile, isobutyl bromide, and potassium carbonate were heated at 80° C. in DMF in the presence of tetra-n-butylammonium bromide to obtain 5-bromo-2-isobutoxybenzonitrile. F: 254, 256.

출처 및 근거

ORD 기록
ord-aee1c62044554355a8da3e52e9a97607
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08067446B2

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