3-Fluorophenol → Ethyl 2,2-difluoro-2-(3-fluorophenoxy)acetate

HRID 56294

반응식

HRID 56294 반응식
[F:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.Br[C:10]([F:17])([F:16])[C:11]([O:13][CH2:14][CH3:15])=[O:12].C([O-])([O-])=O.[K+].[K+]>CO>[F:16][C:10]([F:17])([O:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=1)[C:11]([O:13][CH2:14][CH3:15])=[O:12]

참가 물질

5

반응물 3

HCID 97433-FluorophenolHCID 11430Potassium CarbonateHCID 69585Ethyl bromodifluoroacetate

생성물 1

HCID 66455005Ethyl 2,2-difluoro-2-(3-fluorophenoxy)acetate

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
70 °C

실험 절차

A mixture of 3-fluorophenol (2.24 g, 20.0 mmol), ethyl 2-bromo-2,2-difluoroacetate (8.12 g, 40.0 mmol) and K2CO3 (6.91 g, 50.0 mmol) in MeOH (20 mL) was stirred at 70° C. overnight. It was then cooled to rt and filtered and the filtrate was concentrated in vacuo to give the title compound, which was used for next step without further purification.

후처리

  1. temperatureIt was then cooled to rt
  2. filtrationfiltered
  3. concentrationthe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-47bd33ea822e493bb4ab17fa47d0f8ef
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434695B2

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