1,3,4-Thiadiazol-2-amine → 3-(1H-indazol-5-yl)-2,2-dimethyl-3-phenyl-N-(1,3,4-thiadiazol-2-yl)propanamide

HRID 563365

반응식

HRID 563365 반응식
[NH:1]1[C:9]2[C:4](=[CH:5][C:6]([CH:10]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:11]([CH3:16])([CH3:15])[C:12](O)=[O:13])=[CH:7][CH:8]=2)[CH:3]=[N:2]1.[NH2:23][C:24]1[S:25][CH:26]=[N:27][N:28]=1>>[NH:1]1[C:9]2[C:4](=[CH:5][C:6]([CH:10]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:11]([CH3:16])([CH3:15])[C:12]([NH:23][C:24]3[S:25][CH:26]=[N:27][N:28]=3)=[O:13])=[CH:7][CH:8]=2)[CH:3]=[N:2]1

참가 물질

3

반응물 2

HCID 199091,3,4-Thiadiazol-2-amineHCID 592527643-(1H-indazol-5-yl)-2,2-dimethyl-3-phenylpropanoic acid

생성물 1

HCID 249367303-(1H-indazol-5-yl)-2,2-dimethyl-3-phenyl-N-(1,3,4-thiadiazol-2-yl)propanamide

실험 절차

The title compound was prepared from 3-(1H-indazol-5-yl)-2,2-dimethyl-3-phenylpropanoic acid (Example 29(d)) (44 mg, 0.15 mmol) and 2-amino-1,3,4-thiadiazole using General Coupling Method A to give 29 mg (51% yield) of Example 30. MS found: (M+H)+=378.

출처 및 근거

ORD 기록
ord-ec9ba265c0d8447a8de3f1035647735b
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08067447B2

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