Methyl morpholine oxide → 2-Bromo-5-(trifluoromethyl)benzaldehyde

HRID 563458

반응식

HRID 563458 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[CH2:12][OH:13].C[N+]1([O-])CCOCC1>C(Cl)Cl.CC#N.[Ru]([O-])(=O)(=O)=O.C([N+](CCC)(CCC)CCC)CC>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:9])([F:10])[F:11])=[CH:4][C:3]=1[CH:12]=[O:13]

참가 물질

6

반응물 2

HCID 82029Methyl morpholine oxideHCID 27562482-Bromo-5-(trifluoromethyl)benzyl alcohol

생성물 1

HCID 70180472-Bromo-5-(trifluoromethyl)benzaldehyde

시약·촉매·용매 3

HCID 178419074HCID 178419074, 화합물촉매HCID 6342Acetonitrile용매HCID 6344Dichloromethane용매

실험 절차

To (2-bromo-5-trifluoromethyl-phenyl)-methanol (2.216 g, 8.69 mmol) and N-methylmorpholine N-oxide (2.051 g, 17.38 mmol) in CH2Cl2 (44 mL) and MeCN (2.2 mL) was added tetrapropylammonium perruthenate (0.311 g, 0.87 mmol), and the reaction was stirred at room temperature for 20 minutes. Once no starting material was seen by analytical tlc, the mixture was concentrated and purified by silica gel chromatography to give the title compound.

후처리

  1. concentrationthe mixture was concentrated
  2. custompurified by silica gel chromatography

출처 및 근거

ORD 기록
ord-a84132280b5843aa8010af3d068a986f
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08067445B2

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