참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methyl iodide | HCID 6328 | — |
| 반응물 | Sodium bis(trimethylsilyl)amide | HCID 2724254 | — |
| 반응물 | Ethyl 3-bromo-4-methoxyphenylacetate | HCID 57419861 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-(3-Bromo-4-methoxy-phenyl)-propionic acid ethyl ester | HCID 57458804 | — |
반응 단계
To (3-bromo-4-methoxy-phenyl)-acetic acid ethyl ester (12.2 mmol) in THF was added iodomethane (0.75 mL, 12.2 mmol), and the mixture was cooled to −78° C. Sodium bis(trimethylsilyl)amide (1 M in THF; 12.2 mL, 12.2 mmol) was added, and subsequent work-up gave the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08067445B2 |
|---|
| 출처 데이터셋 | uspto-grants-2011_11 |
|---|
| ORD ID | ord-45b065c0adc14736b6c446ea9622ce3a |
|---|
| 출처 메모 | uspto-grants-2011_11 |
|---|
