反应详情

温度

-78 °C

To (3-bromo-4-methoxy-phenyl)-acetic acid ethyl ester (12.2 mmol) in THF was added iodomethane (0.75 mL, 12.2 mmol), and the mixture was cooled to −78° C. Sodium bis(trimethylsilyl)amide (1 M in THF; 12.2 mL, 12.2 mmol) was added, and subsequent work-up gave the title compound.