2-Chloro-5-nitro-N-(1H-pyrrolo[2,3-b]pyridin-5-yl)-benzamide → HCID 67008363, 화합물

HRID 563999노트

반응식

HRID 563999 반응식
[Cl:1][C:2]1[CH:19]=[CH:18][C:17]([N+:20]([O-])=O)=[CH:16][C:3]=1[C:4]([NH:6][C:7]1[CH:8]=[C:9]2[CH:15]=[CH:14][NH:13][C:10]2=[N:11][CH:12]=1)=[O:5]>C1COCC1.[Pt]>[NH2:20][C:17]1[CH:18]=[CH:19][C:2]([Cl:1])=[C:3]([CH:16]=1)[C:4]([NH:6][C:7]1[CH:8]=[C:9]2[CH:15]=[CH:14][NH:13][C:10]2=[N:11][CH:12]=1)=[O:5]

참가 물질

4

반응물 1

HCID 670082132-Chloro-5-nitro-N-(1H-pyrrolo[2,3-b]pyridin-5-yl)-benzamide

생성물 1

HCID 67008363HCID 67008363, 화합물

시약·촉매·용매 2

HCID 23939Platinum촉매HCID 8028Tetrahydrofuran용매

실험 절차

3.85 g 2-Chloro-5-nitro-N-(1H-pyrrolo[2,3-b]pyridin-5-yl)-benzamide in 600 ml THF were hydrogenated over 2.5 g platinum on carbon at atmospheric pressure over night at RT. The catalyst was removed by filtration and the filtrate evaporated. The residue was purified by chromatography on silica eluting first with ethyl acetate and finally ethyl acetate/methanol mixtures.

후처리

  1. customThe catalyst was removed by filtration
  2. customthe filtrate evaporated
  3. customThe residue was purified by chromatography on silica eluting first with ethyl acetate and finally ethyl acetate/methanol mixtures

출처 및 근거

ORD 기록
ord-d84155c130044411b5548d9df9afe9f9
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08067599B2

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