Phosphorus tribromide → 1-[2-(4-Bromomethyl-phenyl)-ethyl]-4-(5-bromo-pyridin-2-ylmethoxy)-1H-pyridin-2-one

HRID 564142노트

반응식

HRID 564142 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][O:9][C:10]2[CH:15]=[CH:14][N:13]([CH2:16][CH2:17][C:18]3[CH:23]=[CH:22][C:21]([CH2:24]O)=[CH:20][CH:19]=3)[C:12](=[O:26])[CH:11]=2)=[N:6][CH:7]=1.P(Br)(Br)[Br:28]>C(Cl)Cl>[Br:28][CH2:24][C:21]1[CH:22]=[CH:23][C:18]([CH2:17][CH2:16][N:13]2[CH:14]=[CH:15][C:10]([O:9][CH2:8][C:5]3[CH:4]=[CH:3][C:2]([Br:1])=[CH:7][N:6]=3)=[CH:11][C:12]2=[O:26])=[CH:19][CH:20]=1

참가 물질

4

반응물 2

HCID 24614Phosphorus tribromideHCID 670073734-(5-Bromo-pyridin-2-ylmethoxy)-1-[2-(4-hydroxymethyl-phenyl)-ethyl]-1H-pyridin-2-one

생성물 1

HCID 670071711-[2-(4-Bromomethyl-phenyl)-ethyl]-4-(5-bromo-pyridin-2-ylmethoxy)-1H-pyridin-2-one

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To 150 mg (0.36 mmol) 4-(5-bromo-pyridin-2-ylmethoxy)-1-[2-(4-hydroxymethyl-phenyl)-ethyl]-1H-pyridin-2-one (example 12.1a) in 8.0 mL of DCM is added at 0° C. 27 μL (0.29 mmol) phosphorus tribromide. The mixture is stirred 2 h at RT and the formed precipitate is collected. The product is washed with tert-butylmethylether and dried.

후처리

  1. customthe formed precipitate is collected
  2. washThe product is washed with tert-butylmethylether
  3. customdried

출처 및 근거

ORD 기록
ord-b42a32092b4541b8bd34b45b807db58b
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08067590B2

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