Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
6-Methoxy-3-pyridinylamine → m-(Trifluoromethyl)benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 6-Methoxy-3-pyridinylamine | HCID 81121 | — |
| 반응물 | N-[2-({(3R)-1-[1-(6-methoxypyridin-3-yl)piperidin-4-yl]pyrrolidin-3-yl}amino)-2-oxoethyl]-3-(trifluoromethyl)benzamide | HCID 16722463 | — |
| 생성물 | m-(Trifluoromethyl)benzamide | HCID 74535 | — |
반응 단계
N-[2-({3R)-1-[1-(3-ethoxyphenyl)piperidin-4-yl]pyrrolidin-3-yl}amino)-2-oxoethyl]-3-(trifluoromethyl)benzamide was synthesized in similar fashion to N-[2-({(3R)-1-[1-(6-methoxypyridin-3-yl)piperidin-4-yl]pyrrolidin-3-yl}amino)-2-oxoethyl]-3-(trifluoromethyl)benzamide, substituting 3-ethoxyaniline for 6-methoxypyridin-3-amine. The crude product was purified by preparative HPLC. MS m/z: 519 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08067457B2 |
| 출처 데이터셋 | uspto-grants-2011_11 |
| ORD ID | ord-6cd952fe66ec4153a64a02fbd3677703 |
| 출처 메모 | uspto-grants-2011_11 |