Dichloromethane → 2-Amino-5-bromo-3-chlorobenzoic acid

HRID 56447

반응식

HRID 56447 반응식
[NH2:1][C:2]1C(F)=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[Br:12]N1C(=O)CCC1=O.Cl[CH2:21][Cl:22]>>[NH2:1][C:2]1[C:21]([Cl:22])=[CH:9][C:8]([Br:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

참가 물질

4

반응물 3

HCID 6344DichloromethaneHCID 67184N-bromobutanimideHCID 5864082-Amino-3-fluorobenzoic acid

생성물 1

HCID 8279792-Amino-5-bromo-3-chlorobenzoic acid수율 89%

실험 절차

To a solution of 2-amino-3-fluorobenzoic acid (10.0 g, 58.5 mmol) in dichloromethane (150 mL) was added N-bromosuccinimide (10.4 g, 58.5 mmol), and the mixture was stirred at room temperature for 2 hours. LCMS showed the reaction was completed. The solid was filtered and washed with dichloromethane (100 mL×3) to give the title compound as a white solid (13.0 g, 89%), which was directly used in the next step without further purification. MS (ES+) C7H5BrClNO2 requires: 249, 251, found: 250, 252 [M+H]+.

후처리

  1. filtrationThe solid was filtered
  2. washwashed with dichloromethane (100 mL×3)

출처 및 근거

ORD 기록
ord-52336f0ffbfb49cda83f340122f1db83
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434700B2

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