(2-Amino-5-bromo-3-chlorophenyl)methanol → 2-Amino-5-bromo-3-chlorobenzaldehyde

HRID 56449

반응식

HRID 56449 반응식
[NH2:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([Br:9])=[CH:4][C:3]=1[CH2:10][OH:11]>ClCCl.[O-2].[Mn+2]>[NH2:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([Br:9])=[CH:4][C:3]=1[CH:10]=[O:11]

참가 물질

4

반응물 1

HCID 67080684(2-Amino-5-bromo-3-chlorophenyl)methanol

생성물 1

HCID 916663072-Amino-5-bromo-3-chlorobenzaldehyde수율 91%

시약·촉매·용매 2

HCID 160959Manganese oxide촉매HCID 6344Dichloromethane용매

실험 절차

A mixture of (2-amino-5-bromo-3-chlorophenyl)methanol (10.0 g, 42.5 mmol) and manganese oxide (21.9 g, 255 mmol) in dichloromethane (400 mL) was stirred at room temperature overnight. The solid was filtered off, and the filtrate was concentrated to give the title compound as a light yellow solid (9.0 g, 91%), which was directly used in the next step without further purification.

후처리

  1. filtrationThe solid was filtered off
  2. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-7e7701d9d0d548799f1f2084c43bcec7
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434700B2

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