(2-Amino-5-bromo-4-chlorophenyl)methanol → 2-Amino-5-bromo-4-chlorobenzaldehyde

HRID 56455

반응식

HRID 56455 반응식
[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([Br:9])=[CH:4][C:3]=1[CH2:10][OH:11]>ClCCl.[O-2].[Mn+4].[O-2]>[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([Br:9])=[CH:4][C:3]=1[CH:10]=[O:11]

참가 물질

4

반응물 1

HCID 67081018(2-Amino-5-bromo-4-chlorophenyl)methanol

생성물 1

HCID 894196802-Amino-5-bromo-4-chlorobenzaldehyde수율 83.6%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6344Dichloromethane용매

실험 절차

A mixture of (2-amino-5-bromo-4-chlorophenyl)methanol (6 g, 25.5 mmol) and manganese(IV) oxide (15.5 g, 0.178 mol) in dichloromethane (100 mL) was stirred at room temperature overnight. The solid was filtered off, and the filtrate was concentrated to give the title compound as a light yellow solid (5 g, 81%). MS (ES+) C7H5BrClNO requires: 233, 235, found: 234, 236 [M+H]+.

후처리

  1. filtrationThe solid was filtered off
  2. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-6c416bf047144bc99092021fcac746e0
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434700B2

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