Sodium Hydroxide → L-carnosine zinc

HRID 564687노트

반응식

HRID 564687 반응식
[OH-].[Na+].[CH:3]1[N:7]=[CH:6][NH:5][C:4]=1[CH2:8][C@H:9]([NH:13][C:14]([CH2:16][CH2:17][NH2:18])=[O:15])[C:10]([OH:12])=[O:11].O.O.C([O-])(=O)C.[Zn+2:25].C([O-])(=O)C>CO>[CH:3]1[N:7]=[CH:6][NH:5][C:4]=1[CH2:8][C@H:9]([NH:13][C:14]([CH2:16][CH2:17][NH2:18])=[O:15])[C:10]([OH:12])=[O:11].[Zn:25]

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 439224CarnosineHCID 2724192Zinc acetate (USP)

생성물 1

HCID 66778207L-carnosine zinc수율 96.6%

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

Sodium hydroxide (3.51 g) was dissolved in methanol (100 ml), and L-carnosine (9.96 g) was added to the solution to prepare a uniform solution. A solution with zinc acetate dihydrate (9.67 g) dissolved in methanol (145 ml) was added dropwise over 30 minutes to the uniform solution. As a result, white precipitate was gradually formed. After completion of the addition, the mixture was stirred for 2 hours, left to stand overnight and then filtered. The resultant filter cake was then washed with water (140 ml) and air-dried at 80° C. for 5 hours to obtain a crystalline L-carnosine zinc salt (12.4 g) as white powdery crystals.

후처리

  1. customto prepare a uniform solution
  2. additionwas added dropwise over 30 minutes to the uniform solution
  3. customAs a result, white precipitate was gradually formed
  4. additionAfter completion of the addition
  5. waitleft
  6. waitto stand overnight
  7. filtrationfiltered
  8. filtrationThe resultant filter cake
  9. washwas then washed with water (140 ml)
  10. customair-dried at 80° C. for 5 hours

출처 및 근거

ORD 기록
ord-0f2bafe2ea714e9f9806a21ecc13d5af
출처 데이터셋
uspto-grants-2001_01
특허 번호
US06169083A

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