Water → 2-Acetyl-7-methoxyfuro[2,3-c]pyridine-4-carboxylic acid (3-methylpyridin-4-yl)amide

HRID 564735노트

반응식

HRID 564735 반응식
[CH3:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[NH:8][C:9]([C:11]1[C:12]2[CH:21]=[C:20]([C:22](OC)([O:24]C)[CH3:23])[O:19][C:13]=2[C:14]([O:17][CH3:18])=[N:15][CH:16]=1)=[O:10].FC(F)(F)C(O)=O.O>C(Cl)(Cl)Cl.ClCCl>[CH3:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[NH:8][C:9]([C:11]1[C:12]2[CH:21]=[C:20]([C:22](=[O:24])[CH3:23])[O:19][C:13]=2[C:14]([O:17][CH3:18])=[N:15][CH:16]=1)=[O:10]

참가 물질

6

반응물 3

HCID 962WaterHCID 6422Trifluoroacetic acidHCID 700816022-(1,1-Dimethoxyethyl)-7-methoxyfuro[2,3-c]pyridine-4-carboxylic acid (3-methylpyridin-4-yl)amide

생성물 1

HCID 867561882-Acetyl-7-methoxyfuro[2,3-c]pyridine-4-carboxylic acid (3-methylpyridin-4-yl)amide수율 83.7%

시약·촉매·용매 2

HCID 6212Chloroform용매HCID 6344Dichloromethane용매

실험 절차

2-(1,1-Dimethoxyethyl)-7-methoxyfuro[2,3-c]pyridine-4-carboxylic acid (3-methylpyridin-4-yl)amide (0.15 g), trifluoroacetic acid (0.23 ml) and water (0.50 ml) were stirred at 50° C. in chloroform (20 ml) for 4 h. The mixture was cooled and diluted with dichloromethane (30 ml), washed with saturated sodium bicarbonate solution (30 ml) then water (30 ml), dried over magnesium sulfate, filtered and the solvent removed in vacuo to give the title compound (0.11 g) as a cream solid.

후처리

  1. temperatureThe mixture was cooled
  2. washwashed with saturated sodium bicarbonate solution (30 ml)
  3. dry with materialwater (30 ml), dried over magnesium sulfate
  4. filtrationfiltered
  5. customthe solvent removed in vacuo

출처 및 근거

ORD 기록
ord-0b1df72aa6ac4ecca8134a7d8c70ac35
출처 데이터셋
uspto-grants-2001_01
특허 번호
US06169090A

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